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Study by Neuwirt et al [93] has shown an ability of proanthocyanidins extracted from grape seeds to suppress the growth of androgen-sensitive prostate cancer cell lines via a few mechanisms including regulating the expression of MAP kinase and activator protein 1
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Additionally, DET1 R306 forms a salt bridge with COP1 D688 (Fig
In oncology, the role of vitamins is particularly important (Table 3) (5, 6)
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