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Effectiveness and safety vary among individuals, necessitating consultation with a healthcare provider before starting supplementation

The American Society of Anesthesiologists (ASA) has provided guidance on GLP-1-RA use prior to surgery based on the pharmacological half-life, advising that daily medications should be held a day before surgery, and weekly GLP-1-RA should be held a week before surgery

Moreover, impaired autophagy is associated with sustained inflammation in tissues and may contribute to the pathogenesis of chronic inflammation (76)

Older adults face steeper deficits because aging reduces the enzymes responsible for natural glutathione production