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Around 10% of people carry genetic variations linked to GLP-1 resistance. These individuals appear to have higher-than-normal levels of the hormone glucagon-like peptide-1 (GLP-1)

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Cellular mechanisms and physiological consequences of redox-dependent signalling

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But, as is often the case in biology, it's not necessarily that simple

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The bark of the cascara sagrada shrub and juice from the leaves of aloe plants have been used for medicinal purposes

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