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and it should be discontinued in patients with an estimated GFR less than 30 mL per minute per 1.73 m 2.13,14 A Cochrane review pooling data from 347 trials revealed no cases of lactic acidosis in more than 70,000 patient-years of metformin use
placebo when combined with a moderate-intensity lifestyle intervention (Supplementary Table 1)
Inicialmente aprobados para controlar la diabetes, la efectividad de los medicamentos para ayudar a las personas a perder peso llev a su aprobacin posterior para ese propsito tambin
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