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Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with a significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.*

Nat Rev Microbiol 2021;19:14154 2

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