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Moreover, knockdown of HNF4 by RNA interference directly resulted in downregulation of the major methionine metabolic enzymes at both the protein expression level and the relative mRNA level (Fig
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Given the 5 to 8 minute plasma half-life, protocols that use subcutaneous injection are working against basic pharmacokinetics
The liberated p53 then transcription-independently activates the pro-apoptotic protein BAX, thereby triggering the execution phase of apoptosis
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