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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures
Its systemic effects make it useful for broader recovery support rather than isolated treatment areas alone
10.1016/j.jhep.2018.10.023 35 GaoY.ZhangP.WeiY.YeC.MaoD.XiaD.et al (2023)
This concept is used when the rate of removal is roughly exponential
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