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A nested case-control study analyzed data from the French national health care insurance system (SNDS) on individuals with T2D treated with second-line anti-diabetes drugs from 2006 to 2018, reported an increased risk of all thyroid cancer and medullary thyroid cancer with use of GLP-1 agonists after 13 years of treatment 47
GSH can be exhausted via inhibiting SLC7A11 by traditional drugs (e.g., sorafenib and sulfasalazine (SAS)) or novel compounds (e.g., erastin), thus inducing ferroptosis (Zhang et al., 2018), tumor protein 53 (TP53) (Sun et al., 2016)
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