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GLP-1 agonists are being used in combination with basal insulin (Dungan & DeSantis, 2016), although this is not an FDA-approved indication (see rxlist.com) they should not be used as a substitute for basal insulin, as this has been found to result in a decline in glycemic control)(Dungan & DeSantis, 2016) Clinical trials indicate it can reduce HbA1c by ~0.8% Undergoes renal clearance, with dosage reduction needed if creatinine clearance falls to 1.5

This approach helps sponsors support treatment while keeping medication spending under review

Is activation of lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and nephrotoxicity

Bottom line: Safety and effectiveness go hand-in-hand