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GIP improves insulin sensitivity in fat tissue, influences lipid metabolism, and appears to enhance the body ability to mobilize stored fat for energy

Importantly, Retatrutide's unique triple receptor agonismtargeting GLP-1, GIP, and glucagon receptorsappears well-tolerated, with adverse events largely consistent with known effects from the broader GLP-1 class, primarily mild gastrointestinal symptoms such as nausea, decreased appetite, and occasional diarrhea, typically resolving within a few weeks of initiation

If the pediatric regulatory submission is accepted and approved, this would extend the Ozempic Pill / Rybelsus indication to patients as young as 10 years old a landmark moment for pediatric endocrinology

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