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Skin & Systemic Effects Improved metabolic efficiency and reduced oxidative stress may contribute to better skin tone, clarity, and overall tissue quality, reflecting enhanced cellular function rather than direct cosmetic action

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After propensity-score matching, the two cohorts (25,820 in each cohort, mean age 58.0 years, 45.4% women, 14.8% Black, 61.2% White, 6.7% Hispanic) were balanced (Table 2)

The 15% threshold matters because clinical literature consistently identifies it as the point where obesity-related comorbidities begin resolving