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In addition, glutamate signal transduction in neurons is augmented by dopamine, therefore, nigral neurons, i.e., substantia nigra pars compacta neurons, are highly susceptible to glutamate excitotoxicity effects (85)
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Furthermore, many have known therapeutic relevancesuch as platinum and other heavy metals like ruthenium, iridium, rhodium, and palladiumand electronic or photochemical properties that enable additional applications, such as photodynamic therapy, molecular imaging, and targeted drug delivery
However, a high level of these molecules is found in chronic pathologies and viral infections
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