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Post-translational processing of POMC into mature -MSH necessitates well-coordinated actions of several enzymes including carboxypeptidase E (CPE) and -amidating monooxygenase (PAM), which co-localize in POMC-expressing cells (Cawley et al, 2016)
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patents begin expiring in 2031, it could be several more years before multiple generic versions are widely available
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