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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment

Personalized Treatment Plan: Based on the comprehensive assessment, a tailored plan is created, including the appropriate US FDA-approved medication, dosage, and duration

Acknowledgements We thank the School of Biomedical Sciences and CHIRI for financial support and excellent research facilities, respectively

Radtke et al., 2012)