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Results Increased IGF1R amplification and mRNA expression, as well as upregulation of IGF1R protein expression in tumor samples and serum in NSCLC patients To explore genomic alterations and mRNA expression of IGF1R in patients with NSCLC, we used the cBio Cancer Genomics Portal (cBioPortal)
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Instituto Australiano del Deporte
PDZD8 knockdown markedly shortened MAM perimeter, suppressed the expression of MAM-related proteins IP3R1, glucose-regulated protein 75 (GRP75), and VDAC1, inhibited the interaction between VDAC1 and IP3R1, alleviated mitochondrial dysfunction and ER stress, reduced the expression of ER stress-related proteins, and decreased apoptosis while increased proliferation of pancreatic -cells
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