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How Does Vitamin B12 Help With Hangovers
GIP receptors (GIPRs) are highly enriched in oligodendrocytes within the hypothalamic median eminence, and activation of these GIPRs regulates oligodendrocyte survival and myelin plasticity - this process enhances the entry of GLP-1R agonists into the brain via two key pathways: upregulating vascular endothelial growth factor A (VEGF-A) to increase blood-brain barrier permeability and facilitating GLP-1R agonist traversal of myelinated neuronal axons to target hypothalamic nuclei involved in energy homeostasis, including the ARC and PVN [81]
References: (1) P B Johansen, J Nowak, C Skjrbk, et al (1999) Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats Growth Hormone & IGF Research, Volume 9, Issue 2, May 1999, Pages 106-113
Schlederer M
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