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The same discussion also raised a broader supply chain point: if a small number of upstream manufacturers supply most downstream labs and vendors, then a single finishing-stage issue could propagate across multiple brands

This article is not about replacing them

The FORTRESS study found an excess risk of 1.5 (95% CI = -1.1 to 4.1) oral cleft cases per 1,000 infants exposed to topiramate during the first trimester