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Lack of drugdrug interaction was concluded if the 90% confidence intervals for the area under the plasma concentrationtime curve ratio before and with semaglutide were within a pre-specified interval (0.801.25)
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A network meta-analysis published in the Journal of the Endocrine Society found retatrutide achieved 23.77% weight reduction compared to 16.79% for tirzepatide when standardized across trials, with absolute weight loss of 16.34 kg versus 11.82 kg
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