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A C18 fatty diacid chain attached to lysine at position 26 via a hydrophilic spacer enables reversible binding to serum albumin extending the half-life from approximately 2 minutes (native GLP-1) to approximately 7 days
They also made specific amino acid substitutions that provide resistance to DPP-4, an enzyme that rapidly degrades natural GLP-1
The most common gastrointestinal side effects include nausea (affecting up to 44% of patients), vomiting, diarrhoea, constipation, abdominal pain, and dyspepsia
Ensuring proper hydration and electrolyte balance can also help
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