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Dieses Syndrom kann auf eine mitochondriale Toxizitt hinweisen, die durch die HIV-Infektion sowie die zu ihrer Behandlung eingenommenen antiretroviralen Medikamente verursacht wird, was wiederum zu einen Carnitinmangel fhren kann, der den mitochondrialen Fettstoffwechsel beeintrchtigt

Once there exists an accumulation of DAMPs, it would trigger the amplification of tissue inflammation, leading to more severe inflammation and CD, forming a vicious circle and disrupting the normal physiological function of tissues and organs (Linkermann et al., 2014

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