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The remaining calories should come from healthy fats found in plant-based oils and other foods
Phase 2 clinical trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) demonstrated substantial weight reduction in participants with obesity
Large randomized trial meta-analyses in humans have not confirmed a statistically significant increase in MTC, though pharmacovigilance signals exist and the question is not fully settled
Putting It All Together: Is Semaglutide a Game-Changer for Belly Fat
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