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Kber F, Heimann Y, Lehmann T, Schleuner E, Proquitt H, Groten T

A Phase 1 Dose-Escalation Study of Milademetan in Combination with 5-Azacitidine (AZA) in Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndromes (MDS)

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99 However, knockdown of bromodomain-containing protein 4 (BRD4), an essential member of the bromodomain and extra-terminal domain (BET) family and epigenetic reader, markedly reduces H4K8la level, increasing A1 polarization in astrocytes and promoting neuronal death by pro-inflammatory factors such as IL-6, IL-1, and TNF-