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This hormonal cascade works as follows: The hypothalamus releases gonadotropin-releasing hormone (GnRH) GnRH signals the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) LH stimulates the Leydig cells to produce testosterone Rising testosterone feeds back to the hypothalamus and pituitary to regulate production (negative feedback loop) Testosterone is responsible for: Muscle protein synthesis and lean body mass maintenance Bone mineral density Red blood cell production Libido and sexual function Energy, mood, and cognitive function Fat distribution and metabolic health Normal total testosterone in adult men ranges from approximately 300 to 1,000 ng/dL, with levels declining by roughly 1 to 2 percent per year after age 30 (Harman et al., 2001)

2 About 15% of American adults, or 37 million people, are believed to have CKD

Our recommendation To tackle skin inflammation, irritation and redness: Select a cream or lotion formulated with calming ingredients like aloe vera , colloidal oatmeal , ceramides , chamomile , and zinc which can soothe inflamed skin and alleviate redness