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BPC-157's documented ability to modulate the nitric oxide pathway and reduce inflammatory cytokine expression in animal models suggests a potential role in the anti-inflammatory toolkit available to longevity-focused medicine, though this remains an extrapolation requiring human validation

The exact nature of this relationship is still under investigation, and researchers theorize that the connection may be due to a low-fiber diet or taking non-fiber laxativesrather than melanosis coli itself

doi: 10.1016/j.phrs.2022.106320 74 AmorSPuentesFBakerDvan der ValkP

Restless Legs Syndrome Is Associated with Mast Cell Activation Syndrome. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, vol