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Both their pulmonary CD8 and CD4 T-cells show 2- to 3-fold greater expression of HLA-DR and CD38, which are markers of immune activation, compared to seronegative adults (75)
Before fluorescence-activated cell sorting (FACS) analysis, BALF samples were collected, washed and fixed with 4% paraformaldehyde, and lysis of red blood cells with ammonium-chloride-potassium (ACK) lysing buffer was performed for blood samples according to the manufacturers instructions
Across GLP-1 and incretin-based therapies, we are seeing outcomes beyond the scale: - fewer major cardiovascular events - kidney protection - improvements in conditions tightly linked to cardiometabolic dysfunction, including sleep apnea biology We should stop treating obesity as a cosmetic problem and start treating it like the systemic disease driver it is, across joints, heart, kidneys, and sleep
