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Rather than activating the growth hormone receptor, AOD 9604 functions as a pathway-specific modulator of lipid metabolism, enabling investigation of lipolysis and energy regulation in experimental systems without engagement of IGF-1mediated endocrine signaling
Two reasons: (1) similar half-lives (~7 days each) make a single weekly protocol pharmacokinetically practical, and (2) the GLP-1 + amylin combination engages two complementary metabolic pathways
Critically, patients who discontinued treatment saw fat return to baseline within 26 weeks, confirming the effect requires continued use to maintain
The author received no specific funding for this work
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