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69 In comparison, newer oral small-molecule GLP-1 RAs, such as danuglipron and orforglipron, have demonstrated similar efficacy
GLP-1 is released from intestinal L-cells in a biphasic pattern following meal ingestion: an initial early peak within 1015 minutes, driven primarily by neural and endocrine signals from the upper gastrointestinal tract, is followed by a sustained second peak at 3060 minutes driven by direct nutrient contact with L-cells in the distal ileum and colon
It is going to take a lot for someone to wrestle that away from them, at least in the near future. And as for amylin analogs, Papamargaritis, the Leicester researcher, says that, based on current data, Lillys molecule is leading in terms of the amount of weight loss it can offer, but that doesnt mean the market doesnt have a place for other amylin analogs as well as drugs that target other receptors, such as glucagon
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