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Use a vehicle control: keep the solvent level the same in treated and control samples

C.Di CarloV.Guallar-GarridoS.Plaza-GarcaS.et al (2024)

In this trial, 342 men with sildenafil-failure ED were given either intranasal PT-141 (10 mg dose) or placebo on demand over ~48 weeks.The outcomes demonstrated a clear benefit of bremelanotide: About 33.5% of men on bremelanotide achieved a positive clinical response (improved erections sufficient for intercourse) compared to only 8.5% on placebo