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Type 2 diabetes mellitus pharmacological remission with dapagliflozin plus oral semaglutide
First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Gu et al., 2025)
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Salam MA, Al-Amin MY, Salam MT, et al
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