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Upon measurements of cAMP accumulation as a readout of G s activation, Ex4 acted as a potent agonist on rGLP-1R with an EC 50 of 102 pM (log EC 50
ToxDetox should not be used during breastfeeding or pregnancy, as the toxins would then be passed on to the baby
De-identified data of the MGBB that supports this study is available from the MGB Biobankportal at Restrictions apply to the availability of these data, which are available to MGB-affiliated researchers via a formal application
GIP also enhances insulin secretion and may have additional effects on metabolism, though the precise mechanisms contributing to weight loss are not fully understood
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