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Revenue that likely exceeded most of the 72 FDA-registered 503B outsourcing facilities in the country
Metformin passes into breast milk in minimal amounts, whilst insulin molecules are too large to transfer significantly and would be digested in the infant's gastrointestinal tract
In terms of study subjects, the focus was on patients with T2DM, T2DM patients complicated with cardiovascular diseases, or animal models of diabetes-related heart diseases
Substantial weight loss may also affect DOAC dose criteria for some agents (e.g., apixaban and edoxaban in patients 60 kg) and warrants clinical review
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