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This does not establish a human appetite or weight-loss effect
One of the commonly reported microbiome differences between obese/HFD-fed animals and lean controls is an increased Firmicutes : Bacteroidetes ratio 43,44
It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals
The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone
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