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Although this is an attractive approach that spurred great interest, caution should be exercised as standard dosing may be a challenge depending on individual inhalation technique
In addition, equol improves IVM in porcine oocytes by activating the Nrf2/KEAP1 antioxidant pathway, decreasing ROS levels, and increasing the expression of haem oxygenase (HO-1), catalase(CAT), glutathione peroxidase 1 (GPX1) and SOD, and attenuating OS [111]
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