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First synthesized in the 1980s at the University of Arizona during research on UVindependent pigmentation, Melanotan II peptide is supplied as a highpurity (9899% by HPLC) lyophilized powder for laboratory research applications

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In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

Clinicians should conduct a thorough medical history and relevant physical examination for patients with pigmented lesions to identify possible adrenal, gastrointestinal, or genetic disorders that are commonly associated with these types of lesions