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Research published in Scientific Reports demonstrates that aged mice treated with NNMT inhibitors showed approximately 40% greater grip strength compared to untreated controls, remarkably surpassing even the benefits achieved through intensive exercise alone, which produced only 20% improvement
Under these circumstances, ketone bodiesespecially -hydroxybutyrate derived from FAOserve as vital alternative energy substrates (29, 30)
"La introduccin de tratamientos farmacolgicos que pueden modificar estos mecanismos hormonales ofrece una nueva esperanza para enfrentar este ciclo aparentemente inevitable de prdida y ganancia de peso ", menciona la doctora Monereo
If in fact future studies robustly establish a beneficial effect of the drug class in HF, it may allow for broader adoption of GLP-1 RAs in the prevalent CVD, ultimately contributing to addressing the unmet medical need that continues to persist in the prevention or management of, in particular, HFpEF
