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This highlights the need for dedicated clinical trials to evaluate GLP-1 RAs in AS, where these pleiotropic mechanisms may have a large impact
Hyperuricemia may affect the neuroprotective effect of serum UA in patients with MCI [124, 126, 127]
Lisdexamfetamine commonly causes increased heart rate and elevated blood pressure, particularly at higher doses
As a key trial evaluating the efficacy of tirzepatide, SURMOUNT-1 (NCT04184622) was consistent with the SURPASS studies in demonstrating dose-dependent weight loss [66]
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