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Relative and absolute MACE risk estimates for semaglutide vs placebo To remove the potential impact of the CV effects of active comparators on the analysis, a sensitivity analysis was conducted for semaglutide vs placebo comparator data, thereby excluding active comparator data (Additional file 9: Appendix Figure S3)

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Using our substrate profiling method, we showed that the evolved proteases exhibit a highly altered cleavage profile compared to the starting wild-type BoNT/X protease