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Such advances will require interdisciplinary collaboration spanning cardiology, nutrition, genetics, and regulatory sciences, as well as novel trial designs capable of capturing synergistic nutrientdrug and nutrientnutrient interactions over long-term follow-up

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Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

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