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These studies have generally demonstrated positive therapeutic outcomes, but translation to clinical applications requires careful consideration of species differences and experimental limitations

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On the other hand, individuals with a slower metabolism or mild deficiency might experience prolonged benefits

A case-control study based on the National Birth Defects Prevention Study (NBDPS) that included data from 30,630 mothers of infants with birth defects and 11,478 control mothers with infants without major birth defects from the period of October 1997 to December 2011 found that the use of fluoxetine and paroxetine was associated with certain CHDs