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Exenatide and lixisenatide are primarily cleared through the kidneys, while liraglutide, dulaglutide, semaglutide, and tirzepatide undergo proteolytic degradation throughout the body with minimal renal excretion of intact drug
People taking newer drugs like Tirzepatide were 41% less likely to stop treatment compared to those on older medications like Liraglutide
Montero A et al
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