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Some reported or potential side effects include nausea, facial flushing, decreased appetite, headache, fatigue or drowsiness, yawning/stretching, injection-site irritation, and changes in arousal or spontaneous erections
In one study [16], AdIGF-1-infected MSCs were fixed in fibrin glue and implanted in rat cartilage defects, which led to satisfactory cartilage repair (type II collagen matrix secretion and hyaline cartilage production)
This is not usually a problem for Threshold Substances (at least not now see below for historical injustices relating to Threshold Substances), as an adjustment is made, as set out in Technical Document TD2019DL, in order to avoid the risk of false positives arising from an athletes hydration status
While the former was primarily managed with insulin or metformin to control glucose levels, the latter was often treated with lifestyle interventions or less effective pharmacotherapy
