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Intracellular succinate can also be exported to the extracellular space and enter the circulatory system, such as in skeletal muscle cells, where succinate can be secreted into the extracellular milieu by MCT1 and bind to the succinate receptor-1 (SUCNR-1) on non-myofibrillar resident cells, activating downstream signaling pathways like ERK1/2 and PI3K-AKT [75, 76]
Comparison with in vivo human irritation tests
The current research is better described as promising but still developing
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