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Renal function was assessed by the estimated glomerular filtration rate (eGFR), calculated using creatinine, age, sex and ethnicity through the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI)

Soon after this, in 1907, MA Lane, at the University of Chicago, observed two sets of cells stained differently in the pancreatic islets which he called 'alpha' (A) and 'beta' (B) (Lane)