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Safety Considerations and Who Should Seek Provider Guidance The FDA and major hepatology societies recommend limiting acetaminophen to 3,000-4,000 mg daily in healthy adults
Skipping titration steps or escalating faster than every four weeks significantly increases discontinuation rates due to intolerable GI symptoms
Mental health: While rare, there have been studies that showed patients who have had a history of suicidal ideations start to have recurring thoughts of self-harm while taking this class of medication (GLP-1s)
March 2022: More than four years after launch, Novo Nordisk finally adds gallbladder warnings to the labelunfortunately, too late for thousands of patients who already had their gallbladders removed
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