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A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

doi: 10.1371/journal.pone.0023479 2 BergstromJ.FurstP.NoreeL

This approach provides initial therapeutic momentum while establishing a sustainable long-term strategy

Unlike where LDL internalization (mediated via the LDL receptor) results in a reduction in LDL receptor expression, through the effects of intracellular cholesterol on the activity of SREBP, macrophage internalization of oxLDL results in increased synthesis of FAT/CD36

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