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The underlying mechanisms for these beneficial effects appears to be the convergence of complementary signaling pathways and physiological effects (e.g., reduced glucotoxicity, weight loss and BP reduction for SGLT2 inhibitor and reduced glucose-dependent glucagon secretion and anti-inflammatory effects for DPP-4 inhibitor) for beneficial effects on CV health or suppression of microvascular complications [220, 223]
Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): A double-blind, multicentre, randomised, phase 3 trial
This interpretation does not replace current Parkinsons disease models, but it broadens them by locating dopamine loss within a more ancient survival architecture
Based on the depth of corneal infiltration, diverse surgical approaches can be employed, such as amniotic membrane transplantation or conjunctival flap coverage, lamellar or penetrating keratoplasty [111]
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