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[5] Several biological mechanisms have been proposed in preclinical research that suggest plausible links between GLP-1 signalling and brain health: Neuroprotection : In laboratory and animal studies, GLP-1 receptor activation may protect neurons from oxidative stress and inflammation, both of which contribute to neurodegeneration [5] Neurogenesis : Animal studies suggest GLP-1 may promote the growth of new neurons in the hippocampus, a region essential for memory Reduction of amyloid plaques : Preclinical research indicates potential effects on beta-amyloid accumulation, a hallmark of Alzheimer's disease [5] Anti-inflammatory effects : Chronic neuroinflammation is implicated in various forms of dementia The connection between metabolic health and cognitive function provides additional rationale for investigating GLP-1 agents in dementia

Healthy, natural foods are encouraged, not only from the standpoint of interactions with these medications, but for whole body wellness

Reid CT, Tobin AM, Ahern T, et al

NODM is more likely to be a clinical manifestation of PDA and pancreatic precursor lesions because more than 50% PDA related diabetic cases developed diabetes in the 36 months preceding the PDA diagnosis (Setiawan et al., 2019)