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In the nucleus, receptor dimers bind to androgen response elements (AREs) in the promoter regions of target genes, such as prostate-specific antigen (PSA) and transmembrane protease serine 2 (TMPRSS2), etc , to which they recruit various coregulatory proteins to facilitate transcription, leading to responses such as growth and survival 7,8,9,10,11,12
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While none of these findings justify clinical use today, they do raise important questions about how metabolic regulation interacts with a full-body inflammatory disease like endometriosis
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