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Nutrients commonly associated with serotonin metabolism and neural resilience include tryptophan, vitamin B6, magnesium, omega-3 fatty acids, and vitamin D, which help support neurotransmitter production and neural communication

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Common gastrointestinal effects are the most frequently reported adverse reactions, with studies reporting variable rates of digestive symptoms: Diarrhoea and loose stools Abdominal cramping and discomfort Constipation (less common) Nausea and bloating These effects are typically dose-dependent and may improve with gradual dose escalation or taking berberine with meals