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To be included, studies had to involve patients with a diagnosis of IIH according to established diagnostic (including modified Dandy or Friedman criteria) [16], administer a GLP-1 RA as an intervention, and report outcomes of interest such as ICP/CSF opening pressure, headache frequency/severity, visual function, weight/BMI, cognitive measures, and/or safety outcomes

If gastrointestinal symptoms occur, several strategies may help, such as: Starting at a low dose and increasing gradually Eating smaller, more frequent meals Avoiding high-fat and high-fiber foods Staying well hydrated Temporarily pausing or adjusting the medication if needed In some cases, discontinuation may be necessary if symptoms are severe

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Acetaminophen (Tylenol) is generally considered the first-line option for mild to moderate pain in patients taking semaglutide